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Carmen Marco Selected Research

Choline Kinase

2/2022Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines.
8/2021Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors.
1/2019Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells.
1/2018Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors.
3/2016Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).
1/2014Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.
4/2012Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors.

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Carmen Marco Research Topics

Disease

10Neoplasms (Cancer)
02/2022 - 04/2012
5Hepatocellular Carcinoma (Hepatoma)
01/2016 - 04/2002
2Glioblastoma (Glioblastoma Multiforme)
07/2015 - 08/2013
1Carcinogenesis
02/2022
1Scrapie
08/2021
1Alzheimer Disease (Alzheimer's Disease)
08/2018
1Hepatoblastoma
07/2015
1Leukemia
01/2015
1Necrosis
05/2014

Drug/Important Bio-Agent (IBA)

7Choline KinaseIBA
02/2022 - 04/2012
5CholesterolIBA
01/2016 - 06/2009
3Choline (Choline Chloride)IBA
02/2022 - 01/2018
3miltefosine (Impavido)IBA
05/2014 - 06/2009
2EnzymesIBA
02/2022 - 08/2021
2BromidesIBA
03/2016 - 01/2015
2perifosineIBA
07/2015 - 05/2014
1Proteins (Proteins, Gene)FDA Link
02/2022
11,3,4,5,6-pentachlorocyclohexene-1-oxideIBA
02/2022
1Phosphatidylcholines (Phosphatidylcholine)IBA
02/2022
1Phosphorylcholine (Phosphocholine)IBA
02/2022
1Prion ProteinsIBA
08/2021
1PrPSc ProteinsIBA
08/2021
1Amyloid beta-PeptidesIBA
08/2018
1Oxygen (Dioxygen)IBA
03/2016
1Lipoproteins (Lipoprotein)IBA
01/2016
1NitrogenIBA
01/2015
12,2'-Dipyridyl (2,2 Bipyridine)IBA
01/2015
1erucylphosphocholineIBA
05/2014
1edelfosineIBA
05/2014
1Pharmaceutical PreparationsIBA
01/2014
1Caspase 3 (Caspase-3)IBA
01/2014
1Ethanol (Ethyl Alcohol)IBA
04/2002

Therapy/Procedure

2Therapeutics
02/2022 - 08/2013